Document Type : Original Article

Authors

1 Department of Urology, Nizam’s Institute of Medical Sciences

2 Department Of Urology, Narayana Medical College, Nellore

3 Department of Urology, Narayana Medical College, Nellore

4 Department of Urology, Nizam’s Institute of Medical Sciences , Hyderabad

5 Department of Urology, Nizam’s Institute of Medical Sciences , Hyderabad , Telangana ,India.

Abstract

Background: Kidney transplantation gives the best quality of life to chronic kidney disease patients and also increases longevity.
Aim: Analysis of factors responsible for the early and delayed graft functioning in live and cadaver renal transplants
Methods: It was a retrospective observational study. Donor and recipient age, sex, BMI, comorbid illness, and functioning status of the donor kidney, duration and severity of chronic kidney disease and associated bladder disorders were collected. Operative factors like perfusion time, cold ischemia time, blood pressure fall, need for blood transfusion, vasopressor support was recorded. Patients were divided into two groups based on early versus delayed graft function.
Results: 27 cases of Live donor renal transplant and 23 cadaver transplants were included. The average age in live donor and cadaveric transplants was 43.5 ±7.6 years and 38.3 ±10.5 years, respectively. 24 Live Transplant Recipients had Early Graft function (89%). Seven Cadaveric Transplant Recipients had Early Graft function (31%) and 16 of them had Delayed Graft Function (69%). HLA Mismatch, Perioperative Hypotension and BMI of recipient had statistically significant relationship to Early Graft Function with p values of 0.02, 0.004 and 0.007, respectively. With p-value of 0.021 and of 0.046, respectively, perioperative hypotension and cold ischemic time in Cadaveric renal transplantation had statistically significant relationship to Early Graft Function.
Conclusion: Live donor transplants have better early graft function. HLA Mismatch, Perioperative Hypotension, BMI of recipient and cold ischemic time in Cadaveric renal transplantation are the predictors of early graft function.

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