Basrah Journal of Surgery

Abstract

Bone regeneration is a major limiting factor in oral surgery regenerative therapy. The concept of
guided tissue regeneration has provided the strongest evidence that tissue healing can be
influenced exogenously by wound management. At the cellular level, the existence of
osteoprogenitors with the capacity to produce bone in the wound site and the potential to
exogenously influence the behavior of these cells offers the opportunity to further enhance
regenerative wound healing. Chitosan, with a chemical structure similar to hyaluronate, has
been implicated as a wound healing agent. The purpose of this research was to evaluate the
effect of chitosan on osteoblast differentiation and bone formation in vitro.