Tolosa-Hunt syndrome (THS) has been described as a painful, unilateral, partial or total
ophthalmoplegia caused by a nonspecific granulomatous process in the cavernous sinus, the
superior orbital fissure, or the orbital apex. This syndrome should be differentiated from other
lesions involving the cavernous sinus region, such as meningiomas lymphomas, posterior
communicating artery aneurysms, intracavernous carotid aneurysms, both sellar and parasellar
tumors and carotid cavernous fistulae. We report a case of Tolosa-Hunt syndrome in a 39 years
old patient who presented with cranial nerve palsies.
In conclusion, this syndrome should be differentiated from other lesions involving the cavernous
sinus region, such as meningiomas or lymphomas. It should also be distinguished from
ophthalmoplegic migraine and giant cell arteritis.