Document Type : Research Paper
Authors
1 Specialist orthopedic surgeon, Basra Arthroplasty Center/ Basra Teaching Hospital/Albasra Health Directorate
2 Pharmacologist, college of medicine , university of basrah. Member of royal college of surgeons of england
Abstract
Background: Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are widely performed surgical procedures aimed at relieving pain and restoring function in patients suffering from advanced osteoarthritis or other degenerative joint diseases. Pregabalin and Celecoxib, two medications with distinct mechanisms of action, have emerged as valuable components in multimodal analgesic strategies for TKA and THA. We explored the combined effect resulting from the utilization of Pregabalin and Celecoxib in the context of TKA and THA, focusing on their benefits in improving postoperative pain management.
Patients and Methods: We enrolled 87 patients who had TKA and THA between January 2022 and November 2023; they were divided into two groups: The Pregabalin + Celecoxib (group Ⅰ) and the Celecoxib alone (group Ⅱ). Two weeks before surgery, each group received an individualized preventive analgesia regimen. Following surgery, the groups' pain scores and side effects were assessed and compared.
Results: The mean pain score of group Ⅰ was significantly lower than the mean pain scores of (group Ⅱ) at both 6 (P=< 0.001) and 12 (P=< 0.001) hours postoperatively. Eight cases of dizziness were observed in (group Ⅱ).
Conclusion: Celecoxib and Pregabalin both before and following TKA and THA reduced pain and enhanced physical function more than Celecoxib alone.
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