BACKGROUND: Peritonitis is one of the common emergencies and multiple organisms have been implicated in the pathogenesis. Inappropriate and prolonged use of antibiotics have been attributed to the emergence of antibiotic resistance. METHODS: Retrospective observational study, from 1st January 2018 to 31st December 2019(Two years). Patients with secondary peritonitis undergoing surgery are included in this study. Common pathogens and its antibiotic sensitivity pattern from peritoneal fluid, blood and surgical site were studied. RESULTS: Perforation peritonitis is the most common cause of peritonitis. Cefaperazone-sulbactum and Piperacillin-tazobactum were the common empirical antibiotics prescribed. Escherichia coli followed by Klebsiella pneumonia were the commonest microorganism isolated from the peritoneal fluid and found to have adequate sensitivity for the empirical antibiotics. Enterococus and candida were the common organism isolated in blood culture. E-coli and Klebsiella from wound swab showed higher resistance to the empirical antibiotics. Large intestine perforation has higher percentage of surgical site infection. CONCLUSION: E-coli and Klebsiella pneumoniae were the common cause of secondary peritonitis. The empirical antibiotic is shown to be sensitive to the common organism isolated from peritoneal cavity. Wound swab isolates have shown higher resistance to antibiotics hence isolating the organism and assessing the sensitivity might be prudent. Due to geographical variation of antibiotic resistance trends to microorganism, it is prudent to have antibiotic surveillance on a local basis that can recommend appropriate antibiotics.