Ihsan S Sahi*, Mukhallad A Ramadhan@ & Sadiq U Khadim#
*CABS, Head, Dept. of Surgery. @#MSc, Department of Pathology, University of Missan, College of Medicine, Missan, IRAQ.
Benign prostatic hyperplasia (BPH, benign prostatic hypertrophy), a non-malignant abnormal growth of the prostate gland, affects almost all men in some degree as they age and can cause a significant disruption of lifestyle due to urinary outflow obstructive and irritative symptoms.
The present study was performed on patients with BPH and other group of normal persons (40 person for each) to evaluate some of hormonal changes that result in BPH. The blood samples were collected from the groups of study those were of ages 45 and more and serum levels of both estrogen and testosterone were evaluated, as well as tissue of prostate were collected from some of the patients after surgery and estrogen receptors were estimated by immunohistochemisitry.
The results shows significant reduction of the testosterone with elevation of the estradiol levels with marked expression of estrogen receptors in both epithelial and stromal cells of the prostate in patients.
In conclusion, the present study found that sex hormonal disturbances associated with increase age of the person was implicated in the pathogenesis of BPH.