Nawfal Ali Mubark
MB, ChB, DA, FICMS, Lecturer in Anesthesiology, Department of Surgery, College of Medicine, University of Basrah, IRAQ.
The objective of this study is to evaluate the evidence of bronchospasm in patients with hyper-reactive airway disease (HRAD) following induction of anesthesia by thiopental sodium.
The number of the patients participating in this study was 200. Patient`s physical status was class I and II according to American society of anesthesiologists (ASA). Age range was 17-55 years. Patients were subjected to different types of elective operations.
The patients were assigned into two groups: - first group was100 patients with normal airway considered as control group (group A) their age range was 17-55 years with a mean ±SD 30.3±9.95.
The second group included 100 patients with asymptomatic hyper-reactive airway disease which was the case group (group B) their age range was 17 -50 years with a mean ±SD 30.60 ±8.29.
From each patient a full history was taken and auscultation of the chest before induction of anesthesia was done, then oxygenation for 5 minutes with 100% oxygen was achieved without premedication. Anesthesia was induced by sleeping dose of intravenous (IV) thiopental and oxygenation was carried out by face mask, followed by auscultation of the chest immediately. Intubation was achieved with l mg /kg IV of Suxamethonium followed by assisted ventilation of the lung, and then re-auscultation of the chest was performed.
The frequency of bronchospasm after thiopental induction in different types of hyper-reactive airway diseases of the case group was: 14 patients (58.3 %) from the total 24 case who they were a known case of bronchial asthma were developed bronchospasm while only 2 patients (2.9%) from the total 41 case who they have allergic bronchitis were developed bronchospasm, but no one with allergic rhinitis patients had bronchospasm. The differences among different types of hyper-reactive airway diseases of the case group (disease group) regarding the evidence of bronchospasm is of statistically significant with P-value less than 0.05.It is concluded from this study that thiopental is not contraindicated in all patients with HRAD especially those with allergic rhinitis & allergic bronchitis who they don`t have brochospasm while its contraindicated in bronchial asthma who they have bronchospasm preoperatively.