THE EFFECT OF URSODEOXYCHOLIC ACID AS A CONSERVATIVE TREATMENT OF SECONDARY COMMON BILE DUCT STONES IN PREPARATION FOR LAPAROSCOPICAL CHOLECYSTECTOMY
Basrah Journal of Surgery,
2012, Volume 18, Issue 1, Pages 67-74
AbstractCalculus cholecystitis with secondary bile duct stones is a surgical problem that solved by many surgical/conservative options. In our study we use oral Ursodeoxycholic acid as a medical dissolution therapy for secondary common bile duct stones in preparation for cholecystectomy. The study aimed to see the effects of ursodeoxycholic acid on biliary stone dissolution in our locality.
A prospective study on twenty one patients presented with calculus cholecystitis and CBD stones from January 2010 to January 2011 involved in this study, they received oral Ursodeoxycholic acid (ursogall, UDCA) in a dose of 300 mg twice daily p.o over period of four to six weeks & some of them repeat course of treatment.
During the period of observation, seventeen patients respond to medical treatment showed decrease or absence of jaundice and four patients show no response.
It is concluded that: This study illustrate that we can use bile acids as medical dissolution treatment in some indicated patients with CBD stones, there is a chance of conservative treatment to be a way of treating patients with obstructive jaundice due to common bile duct stones, although the number of patient is small owing to the natural occurrence of such cases all over the world and we are lacking the standard facilities of identical research equipment and the comparative differentiation between diseased patients and control cases ; our results need further research with big number of patients and more elements of investigations.
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