Document Type : Original Article


1 Department of Periodontics, College of Dentistry, University of Baghdad

2 B.D.S., M.Sc. Periodontics/ Assistant Professor/ Periodontist College of dentistry, University of Baghdad, Baghdad, Iraq


Background: Periodontitis is universally agreed to be an inflammatory disease that arises as a consequence of the interaction between periodontal pathogens and the host’s immune response, oxidative stress might be one of the most significant contributors to the development and progression of periodontitis. One of the most significant markers of oxidative stress is a molecule called 8-OHdG.
Aim of the study: Analyzing the levels of 8-OHdG in saliva of periodontitis/obese patients in comparison to healthy controls with analysis of its correlation with various clinical periodontal parameters.
Materials and methods: 110 subjects (30 obese, 30 periodontitis, 30 obese periodontitis and 20 healthy subjects) took part in the study. Salivary samples were obtained from all subjects prior to clinical examination. Full periodontal examination was conducted for each participant which entailed plaque index PLI, bleeding on probing BOP, probing pocket depth PPD and clinical attachment loss CAL. Obesity was assessed by using body mass index BMI.
Results: It was showed that periodontitis patients and obese patients had significantly elevated concentrations of salivary 8-OHdG when compared with healthy subjects. Also these levels correlated positively with CAL in obese periodontitis patients.
Conclusions: This study revealed an association between 8-OHdG and periodontitis which suggests that this biomarker plays some part in the pathogenesis of periodontal disease. Moreover, this study showed an association between this biomarker and obesity measures, which suggests that periodontitis and obesity are interconnected via oxidative stress.


Main Subjects

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