Keywords : OXIDATIVE ASSAULT
Basrah Journal of Surgery,
2011, Volume 17, Issue 1, Pages 0-0
Saad S Hammadi*, Salman K Ajlan@, Asal B. Shindi# & Abdul-Sattar
*MB,ChB, FICMS, Professor, Department of Medicine. @MB,ChB, MSc, Assist Professor, Department
of Biochemistry. #MB,ChB, MSc, Assist Professor, Department of Surgery College of Medicine,
University of Basrah, Basrah, IRAQ. %FICMS, Department of Medicine, Al-Faiha General Hospital,
Address of Correspondence:
Dr Saad S. Hammadi. Department of Medicine, College of Medicine, University of Basrah, Basrah, IRAQ.
This study aimed to evaluate the degree of oxidative stress associated with magnetic
resonance imaging (MRI) examination.
Serum malondialdehyde (MDA) levels were estimated in 70 patients, 44 males and 26 females,
16-70 years of age underwent MRI examination for various reasons.
There was an overall increase in serum MDA level following MRI examination with overall
mean difference between pre- and post- MRI examination MDA level of 0.066 ±0.110 Mmole /l
Variables causes significant elevation of serum MDA level included, age older than 25 years
(P-values for 25-44 years, 45-64 years and >=65 were <0.001, < 0.05 and 0.001 respectively),
MRI examination of durations shorter than 20 minutes (P<0.05) and MRI examinations of the
brain (P<0.01) and the abdomen (P<0.05). On the other hand, parameters of no significant
effect on MDA levels included younger ages, MRI examinations of durations longer than 20
minutes, systemic diseases and MRI examination of the spine (P>0.05).
It is concluded that MRI examination is associated with significant free radical activity reflected
by marked elevation of serum MDA levels. This implies that MRI examination may impose an
oxidative assault which in turn, may be of clinical significance in elderly patients in particular.