Print ISSN: 1683-3589

Online ISSN: 2409-501X

Keywords : POLYPS


IMMUNOHISTOCHEMICAL EXPRESSION OF STEM CELL MARKERS CD44, CD166 AND ALDH1A1 IN NON-NEOPLASTIC POLYPS OF THE COLON IN SAMPLE OF IRAQI PATIENTS

Basim Sh Ahmed; Mustafa M Ibraheem; Nawal M Abdullah

Basrah Journal of Surgery, 2017, Volume 23, Issue 1, Pages 37-44
DOI: 10.33762/bsurg.2017.132421

IMMUNOHISTOCHEMICAL EXPRESSION OF STEM CELL MARKERS CD44, CD166 AND ALDH1A1 IN NON-NEOPLASTIC POLYPS OF THE COLON IN SAMPLE OF IRAQI PATIENTS

Nawal M Abdullah*, Mustafa M Ibraheem@ & Basim Sh Ahmed#

*MB,ChB, MSc, Assist. Prof., Department of Anatomy, College of Medicine, University of Basrah. @MB,ChB, MSc, PhD, Assist. Prof., Department of Anatomy, College of Medicine, University of Al-Mustansiryah. #MB,ChB, FICMS, Assist. Prof. Department of Pathology, College of Medicine, University of Al-Mustansiryah, IRAQ.

Abstract
The aim of this retrospective study on tissue specimens of benign colorectal polyps is to evaluate the significance of IHC markers CD44, CD 166 and ALDH1A1 expression in non-neoplastic (Juvenile and Hamartomatous) polyps and their association with different clinicopathological parameters & to compare their expression in benign polyps with that of normal colonic tissue .
Seventy cases enrolled in the study including benign polyps (juvenile & hamartomous polyps) & benign looking colonic tissue obtained from archive of histopathology unit in Gastroenterology and Hepatology hospital in Baghdad Medical City and histopathology unit in Al-Sadder Teaching Hospital in Basrah city for the period Sept. 2015 to Dec. 2016. Four micrometer sections were obtained from formalin fixed paraffin-embedded blocks treated IHC with CD44, CD166 and ALDH1A1 tumor markers.
Majority of polyps were juvenile, no difference regarding gender distribution. The common location was rectum/rectosigmoidal region. CD166, CD44 and ALDH1A1 showed high expression regarding age, gender and location in benign tumors when compared with healthy looking tissue.
In conclusion, colorectal polyps are critical clinical entity and many of them are a precursors to malignant diseases so colonoscopy is essential screening test, polypectomy and follow up is mandatory for patients with colorectal polyps even if they are benign.

THE ROLE OF ALLERGIC RHINITIS IN THE AETIOLOGY OF NASAL POLYPS

Husam Haider; Hashim AL-Abdul Wahed

Basrah Journal of Surgery, 2006, Volume 12, Issue 2, Pages 66-70
DOI: 10.33762/bsurg.2006.55355

THE ROLE OF ALLERGIC RHINITIS IN THE AETIOLOGY OF NASAL POLYPS
Hashim AL-Abdul Wahed*, Husam Haider#
*CABS, FICMS. ENT Dept., Basrah general hospital, Basrah, Iraq, #FRCS, DLO. ENT Dept. Basrah Medical College, Basrah, Iraq
Abstract
Despite the prevalence and long history since nasal polyps were recognized as a clinical entity, many questions still exist with respect to their aetiology & pathogensis, this study aims to assess the role of allergy in the aetiology of nasal polyps based on their epidemiology in Basrah governorate in Iraq & by utilizing the skin test, from January 2000-december 2000 84 patients with simple nasal polyps 50 males & 34 females with age range between 18-70 years were studied by collecting data regarding the history, physical examination& investigations in a questionnaire form .88 normal subjects were also included as a control group. Both patients & controls were subjected to intradermal skin test using seven common aeroallergens.
Out of the 84 patients 58 (69%) had a positive skin test to one or more of the tested allergens, while only 20 (23%) of the control group had a positive test. This difference is statistically significant (p<0.00001), odd ratio=8.0 which means allergic persons were 8 times more prone to have polyps than normal subjects.
Allergy appears to play an important role in the aetiology of nasal polyps and the skin test is useful in the assessment of patients with polyps who may therefore benefit from immuno therapy.